Aktas B M, Vinclair P, Autefage A, Lefebvre H P, Toutain P L, Braun J P
Département des Sciences Biologiques et Fonctionnelles et URA-INRA Physiopathologie et Toxicologie Expérimentales, Ecole Nationale Vétérinaire, Toulouse, France.
J Small Anim Pract. 1997 Dec;38(12):565-9. doi: 10.1111/j.1748-5827.1997.tb03320.x.
Muscle damage in dogs anaesthetised with halothane and propofol was quantified by measurement of the area under the curve of plasma creatine kinase (CK) versus time. Plasma CK remained unchanged during anaesthesia for two and a half and five hours. Following halothane anaesthesia of dogs (resting on one side directly on the surgical table or on cushions, and with or without rotation of the body every 30 minutes), plasma CK was elevated in some animals to 10,000 U/litre by the 12th hour (baseline value < or = 100 u/litre), whereas it remained almost unchanged in other animals. Plasma CK then returned to reference values on day 2 or 3. The mean equivalent of muscle damaged ranged from 0.6 to 0.9 g/kg bodyweight. No muscle damage could be demonstrated in animals anaesthetised with propofol. It is therefore concluded that plasma CK should not be used as a diagnostic aid following halothane anaesthesia because of false positives due to the halothane anaesthesia itself and that propofol is best suited for the investigation of muscle damage due to surgical procedures.
通过测量血浆肌酸激酶（CK）随时间变化曲线下的面积，对用氟烷和丙泊酚麻醉的犬类肌肉损伤进行了量化。在麻醉两小时半和五小时期间，血浆CK保持不变。在用氟烷麻醉犬类后（直接侧卧在手术台上或垫子上，每30分钟身体旋转或不旋转），到第12小时，部分动物的血浆CK升高至10000 U/升（基线值≤100 U/升），而其他动物的血浆CK几乎保持不变。然后血浆CK在第2天或第3天恢复到参考值。肌肉损伤的平均等效量为0.6至0.9克/千克体重。在用丙泊酚麻醉的动物中未发现肌肉损伤。因此得出结论，由于氟烷麻醉本身会导致假阳性结果，血浆CK不应作为氟烷麻醉后的诊断辅助指标，并且丙泊酚最适合用于研究手术操作引起的肌肉损伤。
