Mathai J, Sulochana P V, Sathyabhama S
Division of Blood Transfusion Services, Sree Chitra Thirunal Institute for Medical Sciences and Technology, Trivandrum.
Indian J Pathol Microbiol. 1997 Oct;40(4):553-4.
Bombay phenotype is peculiar in that red cells are not agglutinated by antisera A, B or H; while serum contains anti A, B and H. Existence of modifying genes at independent loci with variable expression of ABO genes is postulated. We report here a case of partial suppression where antigens could be detected by elution tests and unlike classical Bombay type, normal amount of appropriate blood group substances were present in saliva. This case of para Bombay phenotype was detected as a result of discrepancy in cell and serum group ng. This highlights the importance of both forward and reverse grouping in ABO testing.
孟买血型很特殊,其红细胞不被抗A、抗B或抗H血清凝集;而血清中含有抗A、抗B和抗H。推测在独立基因座上存在修饰基因,ABO基因有可变表达。我们在此报告一例部分抑制的病例,通过洗脱试验可检测到抗原,与经典孟买血型不同的是,唾液中存在正常量的相应血型物质。这例类孟买血型病例是由于细胞和血清血型鉴定结果不一致而被检测到的。这突出了ABO血型检测中正向和反向定型的重要性。