Hagino O R, Weller E B, Weller R A, Fristad M A
Brown University, Providence, RI, USA.
J Am Acad Child Adolesc Psychiatry. 1998 Jan;37(1):60-5. doi: 10.1097/00004583-199801000-00018.
Lithium may be useful in the treatment of prepubertal children with bipolar disorder or aggressive conduct disorder. However, there are few dosage guidelines. This study compares two dosage methods reported for prescribing lithium to prepubertal children: (1) a weight-based dosing schedule and (2) a single-dose, kinetics-based method.
Lithium doses were calculated using each method and then compared with doses actually used in the clinical care of hospitalized children.
No statistically significant differences were found between mean lithium dose estimates calculated by the two methods. Average lithium dose estimates for both kinetic and weight-based methods were less than the observed discharge doses. Differences were seen between the two methods for children weighing between 25 and 30 kg.
The weight-based dosing schedule and the single-dose, kinetics-based methods for calculating lithium dose result in similar dosage estimates when applied to young children.
锂盐可能对治疗青春期前患有双相情感障碍或攻击性行为障碍的儿童有用。然而，剂量指南却很少。本研究比较了两种给青春期前儿童开锂盐的剂量方法：（1）基于体重的给药方案和（2）基于动力学的单剂量方法。
使用每种方法计算锂盐剂量，然后与住院儿童临床护理中实际使用的剂量进行比较。
两种方法计算出的平均锂盐剂量估计值之间未发现统计学上的显著差异。基于动力学和基于体重的方法的平均锂盐剂量估计值均低于观察到的出院剂量。体重在25至30千克之间的儿童，两种方法之间存在差异。
当应用于幼儿时，基于体重的给药方案和基于动力学的单剂量锂盐计算方法会得出相似的剂量估计值。
