一些嗜T细胞的人类免疫缺陷病毒将鼠类CXCR-4用作第二受体。
Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses.
作者信息
Parolin C, Borsetti A, Choe H, Farzan M, Kolchinsky P, Heesen M, Ma Q, Gerard C, Palú G, Dorf M E, Springer T, Sodroski J
机构信息
Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
出版信息
J Virol. 1998 Feb;72(2):1652-6. doi: 10.1128/JVI.72.2.1652-1656.1998.
Abstract
The human CXCR-4 molecule serves as a second receptor for primary, T-cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV-1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.
摘要
人类CXCR-4分子作为原发性、嗜T细胞性和实验室适应性人类免疫缺陷病毒1型（HIV-1）毒株的第二种受体。在此我们表明，小鼠CXCR-4能够支持其中一些HIV-1毒株的进入。小鼠和人类CXCR-4在作为HIV-1受体发挥功能的能力上的差异，由CXCR-4蛋白第二个细胞外环中的序列所决定。
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