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[自体血置换在类风湿关节炎手术中的有效性——10年经验报告]

[Effectiveness of autologous blood replacement in rheumatoid arthritis surgery--a report of 10 years experience].

作者信息

Quoss A, Paululat S

机构信息

Anästhesieabteilung, Rheumaklinik Bad Bramstedt.

出版信息

Anaesthesiol Reanim. 1997;22(5):125-9.

PMID:9445534
Abstract

The management and the resulting effectiveness of a four-step autotransfusion concept, consisting of preoperative autologous blood predeposit, isovolaemic haemodilution, preoperative plasmapheresis and intraoperative autotransfusion in rheumatic patients undergoing planned operations associated with considerable blood loss, are presented. In just one case out of 117 primary total joint replacements of the hip or knee that were retrospectively studied in rheumatic patients suffering from chronic anaemia did a homologous erythrocyte concentrate have to be transfused. A 19-year-old patient suffering from juvenile arthritis who underwent a total knee replacement operation had the lowest haemoglobin and haematocrit levels with a perioperative haemoglobin of 4.2 g/dl and a haematocrit of 12.4%. In 1996, 4,073 autologous transfusions were made by the anaesthetic ward. The autotransfusion concept was established in 1988. At that time 47% of the total blood demand was replaced by autologous transfusion. In 1989 there was an increase to 88%, in 1990 to 94%, and in 1991 to 98%. From 1992 up to 1996 the autologous transfusions covered continuously more than 99% of the total blood demand. It is pointed out, that under normovolaemic conditions the chronic anaemia of these rheumatic patients is a contraindication neither for predeposit nor for intraoperative autotransfusion.

摘要

本文介绍了一种四步自体输血方案的管理方法及其效果。该方案包括术前自体血预存、等容血液稀释、术前血浆置换以及术中自体输血,应用于计划进行的、术中失血量大的风湿性疾病患者手术。在对117例患有慢性贫血的风湿性疾病患者进行回顾性研究的初次全髋关节或全膝关节置换手术中,仅1例患者需要输注异体红细胞浓缩液。一名接受全膝关节置换手术的19岁青少年关节炎患者的血红蛋白和血细胞比容水平最低,围手术期血红蛋白为4.2 g/dl,血细胞比容为12.4%。1996年,麻醉科进行了4073次自体输血。自体输血方案于1988年确立,当时自体输血替代了47%的总用血需求。1989年这一比例增至88%,1990年为94%,1991年为98%。从1992年到1996年,自体输血持续覆盖了总用血需求的99%以上。需要指出的是,在血容量正常的情况下,这些风湿性疾病患者的慢性贫血既不是自体血预存的禁忌证,也不是术中自体输血的禁忌证。

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