静脉注射哌替啶后的药理不耐受反应
[Pharmacologic intolerance reaction after intravenous injection of pethidine].
作者信息
Kühl P, Thomas A, Winter M, Gall H
机构信息
Abteilung Dermatologie der Universität Ulm.
出版信息
Anasthesiol Intensivmed Notfallmed Schmerzther. 1997 Oct;32(10):645-7. doi: 10.1055/s-2007-995127.
We report on anaphylactoid reactions (urticae at the injection site and along the injection vein) after intravenous injections of pethidine in two patients. Skin tests with pethidine were negative, but intravenous challenge showed urticae. These results indicate that the reactions were due to a non-immunological mechanism resembling pharmacological intolerance. Retrospective analysis revealed a 5.6% incidence of pharmacological intolerance reactions to intravenous pethidine in 519 patients.
我们报告了两名患者静脉注射哌替啶后发生的类过敏反应（注射部位及沿注射静脉出现荨麻疹）。哌替啶皮肤试验为阴性，但静脉激发试验显示出现荨麻疹。这些结果表明，这些反应是由一种类似于药理学不耐受的非免疫机制引起的。回顾性分析显示，在519例患者中，静脉注射哌替啶引起药理学不耐受反应的发生率为5.6%。
Zotero 插件