Roubos E W
Cell Tissue Res. 1976 Apr 28;168(1):11-31. doi: 10.1007/BF00219720.
The cerebral ganglia of the freshwater snail Lymnaea stagnalis contain two clusters of neurosecretory Caudo-Dorsal Cells (CDC). These cells produce a neurohormone which stimulates ovulation. Ganglion transplantation and quantitative electron microscopy show that neuronal isolation of the cerebral ganglia complex (CCC) results in an activation of the CDC. It was, therefore, concluded that the CDC are controlled by an inhibitory neuronal input originating outside the cerebral ganglia. Ultrastructural studies on synaptic degeneration in the CCC suggest that this input reaches the CDC via a special type of synapse-like structure, the type C-SLS. Furthermore, transplantation of CCC into acceptor snails leads to a reduced release and an increased intracellular brekdown of neurohormone in the CDC of the nervous system of the acceptors. It is supposed that these phenomena are caused by the release of an (unknown) factor from the transplanted CCC. Special attention was given to the formation and degradation of a peculiar type of neurohormone granule, the large electron dense granule. The physiological significance of the neuronal and non-neuronal control mechanisms which regulate CDC activity is discussed.
淡水螺椎实螺的脑神经节包含两簇神经分泌性尾背细胞（CDC）。这些细胞产生一种刺激排卵的神经激素。神经节移植和定量电子显微镜研究表明，脑神经节复合体（CCC）的神经元分离会导致CDC的激活。因此，得出结论，CDC受源自脑神经节外部的抑制性神经元输入的控制。对CCC中突触退化的超微结构研究表明，这种输入通过一种特殊类型的突触样结构，即C型突触样结构（C-SLS）到达CDC。此外，将CCC移植到受体螺中会导致受体神经系统CDC中神经激素的释放减少和细胞内分解增加。据推测，这些现象是由移植的CCC释放一种（未知）因子引起的。特别关注了一种特殊类型的神经激素颗粒，即大电子致密颗粒的形成和降解。讨论了调节CDC活性的神经元和非神经元控制机制的生理意义。
