Zaĭchenko S I
Arkh Patol. 1997 Sep-Oct;59(5):32-6.
20 uteri, 80 placentas and the hearts of 66 normal fetuses from rheumatic mothers have been studied. Exacerbations of rheumatism were observed in some mothers during pregnancy. Sclerosis with enhanced synthesis of collagen type I, III, IV, V and fibronectin was observed in ECM when rheumatism during the pregnancy was not active. Activation of rheumatism during the pregnancy was followed by disturbances of synthesis of interstitial and membrane collagen types, alteration of stromal-parenchymatous relations and development of dyschronosis in the placenta and fetal heart. The study of the heart from children aged 3 months-14 years showed a long-term effect of maternal rheumatism.
对20个子宫、80个胎盘以及66例患风湿性疾病母亲所生正常胎儿的心脏进行了研究。在一些母亲孕期观察到了风湿病情加重。当孕期风湿病情不活跃时，在细胞外基质中观察到I、III、IV、V型胶原蛋白和纤连蛋白合成增强的硬化现象。孕期风湿病情活跃之后，出现了间质和膜型胶原蛋白合成紊乱、基质与实质关系改变以及胎盘和胎儿心脏发育不同步。对3个月至14岁儿童心脏的研究显示了母亲风湿性疾病的长期影响。
