[Immunomorphology of the extracellular matrix of the uterus, placenta fetal and infant heart in maternal rheumatism].

20 uteri, 80 placentas and the hearts of 66 normal fetuses from rheumatic mothers have been studied. Exacerbations of rheumatism were observed in some mothers during pregnancy. Sclerosis with enhanced synthesis of collagen type I, III, IV, V and fibronectin was observed in ECM when rheumatism during the pregnancy was not active. Activation of rheumatism during the pregnancy was followed by disturbances of synthesis of interstitial and membrane collagen types, alteration of stromal-parenchymatous relations and development of dyschronosis in the placenta and fetal heart. The study of the heart from children aged 3 months-14 years showed a long-term effect of maternal rheumatism.