[心脏硬化症中心肌中纤连蛋白及I、III、IV和V型胶原的免疫形态学研究]

[Immunomorphological study of fibronectin and collagen types I, III, IV and V in the myocardium in cardiosclerosis].

作者信息

Shekhonin B V, Idel'son G L, Kotelianskiĭ V E, Chernousov M A, Sotnikov A V

出版信息

Arkh Patol. 1986;48(1):24-31.

Abstract

Fibronectin and collagen, types I, III, IV and V, in the granulation tissue replacing the myocardial infarction, in the focal and diffuse cardiosclerosis were studied by means of the immunofluorescent method. The extracellular matrix in the granulation tissue contained fibronectin and collagen of the above types. Intracellular fibronectin was also found in the necrotized cardiomyocytes. Fibronectin and collagen of type IV were not detected in the postinfarction scars. The extracellular matrix consisted mainly of collagen, types III and V. Fibronectin and collagen, types I, III and V, are observed in the connective tissue in diffuse cardiosclerosis in the presence of the coronary arteries stenosis. No prevalence of the collagen of any type was found.

摘要

采用免疫荧光法研究了在替代心肌梗死的肉芽组织、局灶性和弥漫性心肌硬化中纤连蛋白以及Ⅰ型、Ⅲ型、Ⅳ型和Ⅴ型胶原的情况。肉芽组织中的细胞外基质含有上述类型的纤连蛋白和胶原。在坏死的心肌细胞中也发现了细胞内纤连蛋白。在梗死后期瘢痕中未检测到Ⅳ型纤连蛋白和胶原。细胞外基质主要由Ⅲ型和Ⅴ型胶原组成。在存在冠状动脉狭窄的弥漫性心肌硬化的结缔组织中观察到了Ⅰ型、Ⅲ型和Ⅴ型纤连蛋白和胶原。未发现任何一种类型的胶原占优势。