Mendes L S, Collins S P
Department of Surgery, Clinical Sciences Building, University of New South Wales, Prince Henry Hospital, Little Bay, NSW 2036, Australia.
Pharmacol Res. 1997 Dec;36(6):457-61. doi: 10.1006/phrs.1997.0251.
The therapeutic use of the atypical antipsychotics clozapine, remoxipride and risperidone has been reported to be associated with a reduced occurrence of the extrapyramidal side-effects seen during therapy with classical (or typical) antipsychotics such as trifluoperazine and haloperidol. The aim of this study was to determine the effects of the atypical antipsychotics clozapine, remoxipride and risperidone on rat skeletal muscle in vitro. Remoxipride and risperidone did not produce contracture in muscle. Clozapine induced a small muscle contracture at high concentrations. Pre-treatment of muscle with trifluoperazine or haloperidol in vitro caused the muscle to display contracture responses to halothane, and haloperidol also potentiated a contracture response to caffeine. Pre-treatment of muscle with remoxipride and risperidone did not induce contracture in response to halothane and did not potentiate caffeine contracture. Clozapine pre-treatment caused muscle fibre bundles to display a small halothane-induced contracture and caused significant potentiation of caffeine-induced contracture.
据报道，使用非典型抗精神病药物氯氮平、瑞莫必利和利培酮进行治疗，与使用经典（或传统）抗精神病药物（如三氟拉嗪和氟哌啶醇）治疗期间出现的锥体外系副作用发生率降低有关。本研究的目的是确定非典型抗精神病药物氯氮平、瑞莫必利和利培酮对大鼠骨骼肌的体外作用。瑞莫必利和利培酮未在肌肉中产生挛缩。氯氮平在高浓度时可诱导轻微的肌肉挛缩。体外先用三氟拉嗪或氟哌啶醇预处理肌肉，可使肌肉对氟烷产生挛缩反应，氟哌啶醇还可增强对咖啡因的挛缩反应。先用瑞莫必利和利培酮预处理肌肉，不会诱导对氟烷的挛缩反应，也不会增强咖啡因挛缩反应。氯氮平预处理可使肌纤维束出现轻微的氟烷诱导挛缩，并显著增强咖啡因诱导的挛缩。
