衣壳突变体C6b对HIV复制的抑制作用。
Inhibition of HIV replication by capsid mutant C6b.
作者信息
Shimano R, Iida S, Fukumori T, Yamamoto Y, Kawamura M, Furuta R A, Adachi A
机构信息
Department of Virology, School of Medicine, University of Tokushima, Japan.
出版信息
Biochem Biophys Res Commun. 1998 Jan 14;242(2):313-6. doi: 10.1006/bbrc.1997.7963.
A Gag capsid mutant of human immunodeficiency virus type 1 (HIV-1) designated C6b was biologically and biochemically characterized with respect to its ability to suppress the replication of wild-type (wt) HIV. The C6b efficiently interfered with the replication of wt HIV-1 in the cleavage of Gag precursor, and also in the early replication process before or during viral DNA synthesis after viral penetration. The C6b Gag appeared to be unable to form chimeric multimers with HIV-2 Gag and failed to inhibit the replication of wt HIV-2.
一种名为C6b的1型人类免疫缺陷病毒（HIV-1）的Gag衣壳突变体，就其抑制野生型（wt）HIV复制的能力进行了生物学和生物化学特征分析。C6b在Gag前体的切割过程中，以及在病毒穿透后病毒DNA合成之前或期间的早期复制过程中，有效地干扰了wt HIV-1的复制。C6b Gag似乎无法与HIV-2 Gag形成嵌合多聚体，并且未能抑制wt HIV-2的复制。
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