Suppression of HIV-2 replication by HIV-1 gag mutants.
作者信息
Shimano R, Inubushi R, Fukumori T, Tamaki M, Oshima Y, Kawamura M, Adachi A
机构信息
Department of Virology, The University of Tokushima School of Medicine, Tokushima, 770-8503, Japan.
出版信息
Biochem Biophys Res Commun. 1998 Jul 20;248(2):418-21. doi: 10.1006/bbrc.1998.8975.
Gag gene mutants of human immunodeficiency virus type 1 (HIV-1) were analyzed for their potentials of inhibiting the replication of wild-type (wt) HIV-2, the second AIDS virus, in a single-round of viral replication. Of twenty-two HIV-1 gag mutants examined, seven were found to efficiently interfere with the replication of wt HIV-2. Some mutants, which can suppress the replication of wt HIV-1, did not show this inhibitory effect. These mutants were defective at the late phase of viral replication. A mutant designated NL-C1a was demonstrated to be very effective against the replication of HIV-1 and HIV-2 in monocytic cells as well as in lymphocytic cells.
Zotero 插件