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围产期给予丙酸睾酮对雌性雪貂性行为的影响。

Effects of testosterone propionate administered perinatally on sexual behavior of female ferrets.

作者信息

Baum M J

出版信息

J Comp Physiol Psychol. 1976 Apr;90(4):399-410. doi: 10.1037/h0077220.

DOI:10.1037/h0077220
PMID:944719
Abstract

Female ferrets that received injections of testosterone propionate (TP) early in postnatal life displayed significantly more masculine behavior than did control females when gonadectomized and administered either TP or estradiol benzoate in adulthood. This increased masculine response potential was not correlated with the effects of early TP treatment on phallic development. In contrast to results obtained in most other species, perinatal administration of TP to female ferrets failed to disrupt their ability to display the behavior that is characteristic of the sexually receptive animal in estrus. When estrogenic stimulation was provided in adulthood, the receptive behavior of three groups of perinatally androgenized females was indistinguishable from that of both male and female controls. However, after gonadectomy and administration of TP, control males and females that had received TP prenatally plus on Day 3 were significantly more receptive than were control females. The induction of receptivity by TP was significantly inhibited by simultaneous administration of the antiestrogen MER-25.

摘要

在出生后早期接受丙酸睾酮(TP)注射的雌性雪貂,在成年后进行性腺切除并给予TP或苯甲酸雌二醇时,表现出比对照雌性明显更多的雄性行为。这种增加的雄性反应潜能与早期TP治疗对阴茎发育的影响无关。与在大多数其他物种中获得的结果相反,围产期给雌性雪貂注射TP并未破坏它们表现发情期性接受动物特征行为的能力。当在成年期提供雌激素刺激时,三组围产期雄激素化雌性的接受行为与雄性和雌性对照均无差异。然而,在性腺切除并给予TP后,产前加第3天接受TP的对照雄性和雌性比对照雌性的接受性明显更强。同时给予抗雌激素MER - 25可显著抑制TP诱导的接受性。

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Effects of testosterone propionate administered perinatally on sexual behavior of female ferrets.围产期给予丙酸睾酮对雌性雪貂性行为的影响。
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