Kasuga Y, Kobayashi S, Fujimori M, Shingu K, Hama Y, Ito K, Amano J
Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Endocr J. 1997 Aug;44(4):567-70. doi: 10.1507/endocrj.44.567.
We report herein rare cases who developed hyperthyroid Graves' disease after surgical treatments for thyroid nodules. We have seen only 4 such cases in the course of 1680 consecutive cases (0.24%) of thyroidectomies in which partial thyroidectomy was carried out from 1966 to 1993. It is of interest that because 2 of these three cases (67%) were associated with positive TGHA and/or MCHA at the time of surgery, the presence of autoimmune thyroiditis may predispose to Graves' disease, but surgical treatment of the thyroid glands may not be related to the development of Graves' disease, because the hyperthyroid symptoms appeared 2 to 27 years (mean: 12 years) after the surgery.
我们在此报告甲状腺结节手术后发生甲状腺功能亢进型格雷夫斯病的罕见病例。在1966年至1993年期间连续进行的1680例甲状腺部分切除术病例中，我们仅见到4例此类病例（0.24%）。有趣的是，这4例中有2例（67%）在手术时伴有甲状腺球蛋白抗体（TGHA）和/或甲状腺微粒体抗体（MCHA）阳性，自身免疫性甲状腺炎的存在可能易患格雷夫斯病，但甲状腺手术治疗可能与格雷夫斯病的发生无关，因为甲亢症状在手术后2至27年（平均12年）出现。
