Ehrengut W
Institute of Vaccinology and Virology, Hamburg, Germany.
Acta Paediatr Jpn. 1997 Dec;39(6):658-62. doi: 10.1111/j.1442-200x.1997.tb03663.x.
The impact of different vaccine administrations in the Federal Republic of Germany, in relation to vaccine-associated paralytic poliomyelitis (VAPP) was studied. (This only means that on the basis of the temporal relation of vaccination and onset, the vaccine cannot be ruled out as possible cause). Oral polio vaccine (OPV) was given between 1963 and 1977 only and recommended simultaneously with inactivated vaccines (DT/DPT) between 1980 and 1985. In the first period 10 VAPP cases occurred among 9.96 million estimated vaccinees aged under 2 years. In the second period 6 cases of provocation poliomyelitis (PRP) were found among 2.9 million estimated OPV/DT/DPT vaccinees of the same age group. Statistically the VAPP/PRP frequencies in the two periods studied did not achieve significance.
研究了在德意志联邦共和国不同疫苗接种方式与疫苗相关麻痹型脊髓灰质炎（VAPP）之间的关系。（这仅意味着根据接种疫苗与发病的时间关系，不能排除疫苗作为可能病因的可能性）。仅在1963年至1977年间使用口服脊髓灰质炎疫苗（OPV），并在1980年至1985年间推荐与灭活疫苗（DT/DPT）同时使用。在第一阶段，估计996万名2岁以下接种疫苗者中出现了10例VAPP病例。在第二阶段，在估计290万名同一年龄组的OPV/DT/DPT接种者中发现了6例激发性脊髓灰质炎（PRP）病例。在所研究的两个阶段中，VAPP/PRP的发生率在统计学上没有显著差异。
