Sandhu S S, Denton A, Jarmulowicz M, Pigott K, Kaisary A V
Department of Urology, Royal Free Hospital School of Medicine, London, UK.
Clin Oncol (R Coll Radiol). 1997;9(6):412-4. doi: 10.1016/s0936-6555(97)80142-2.
Pure small cell carcinoma of the prostate is a rare anaplastic tumour. This report presents the clinicopathological findings of two patients presenting with this disease. Immunohistochemistry was positive for protein gene product 9.5, neurone specific enolase and calcitonin. Staining was negative for prostate specific antigen and prostate acid phosphatase. androgen ablation has no place in the management of this lesion and patients with this disease should be managed as if they have a neuroendocrine tumour.
前列腺纯小细胞癌是一种罕见的间变性肿瘤。本报告展示了两名患有该疾病患者的临床病理特征。免疫组化显示蛋白基因产物9.5、神经元特异性烯醇化酶和降钙素呈阳性。前列腺特异性抗原和前列腺酸性磷酸酶染色呈阴性。雄激素剥夺疗法在该病变的治疗中并无作用，患有这种疾病的患者应按照患有神经内分泌肿瘤的患者进行管理。
