Goulet-Salmon B, Berthe E, Franc S, Chanel S, Galateau-Salle F, Kottler M, Mahoudeau J, Reznik Y
Department of Endocrinology Hospital CHU, Caen, France.
J Endocrinol Invest. 2004 Jun;27(6):570-3. doi: 10.1007/BF03347481.
We report the unusual occurrence of a neuroendocrine prostatic tumor in two young males with multiple endocrine neoplasia (MEN) 2B. Immunohistochemistry of the tumor markers may help differentiate a primary neuroendocrine prostate tumor from the metastasis of a medullary thyroid carcinoma of poor prognosis. MEN 2B hallmarks (i.e. plasma thyrocalcitonin and urinary metanephrines) may be systematically investigated in neuroendocrine tumors of the prostate, and conversely prostate examination may be performed in the periodic screening of MEN 2B male patients.
我们报告了两例患有多发性内分泌腺瘤病（MEN）2B型的年轻男性中出现神经内分泌前列腺肿瘤这一罕见情况。肿瘤标志物的免疫组化有助于鉴别原发性神经内分泌前列腺肿瘤与预后不良的甲状腺髓样癌转移灶。对于前列腺神经内分泌肿瘤，可能需要系统地检查MEN 2B的特征（即血浆甲状腺降钙素和尿间甲肾上腺素），反之，在对MEN 2B男性患者进行定期筛查时，也可能需要进行前列腺检查。
