Borst S E, Lowenthal D T
Geriatric Research, Education and Clinical Center, VA Medical Center, Gainesville, FL 32608-1197, USA.
Endocrine. 1997 Aug;7(1):61-3. doi: 10.1007/BF02778065.
Loss of muscle mass and strength are well-known consequences of aging. The growth hormone/IGF-I pathway is both impaired with aging and essential for growth and maintenance of skeletal muscle. Despite this, growth hormone (GH) replacement has not been effective in increasing muscle mass and strength in the elderly. Possible explanations for this failure include 1. The presence of other age-related impairments in muscle that prevent the actions of GH and IGF-I and 2. Complications arising from a failure to deliver GH and IGF-I in the physiologically correct manner. This article summarizes the results of clinical trials of GH and IGF-I in the elderly and discusses the current status of strategies for safely and effectively stimulating the GH/IGF-I pathway in this population.
肌肉质量和力量的丧失是衰老的众所周知的后果。生长激素/胰岛素样生长因子-I（GH/IGF-I）通路在衰老过程中受损，同时对骨骼肌的生长和维持至关重要。尽管如此，生长激素（GH）替代疗法在增加老年人肌肉质量和力量方面并未取得成效。对此失败的可能解释包括：1. 肌肉中存在其他与年龄相关的损伤，阻碍了GH和IGF-I的作用；2. 未能以生理上正确的方式输送GH和IGF-I所引发的并发症。本文总结了GH和IGF-I在老年人中的临床试验结果，并讨论了在该人群中安全有效地刺激GH/IGF-I通路的策略的现状。
