Davies A M
School of Biological and Medical Sciences, University of St Andrews, Scotland, UK.
J Anat. 1997 Nov;191 ( Pt 4)(Pt 4):483-91. doi: 10.1046/j.1469-7580.1997.19140483.x.
The accessibility of the primary sensory neurons of the trigeminal system at stages throughout their development in avian and mammalian embryos and the ease with which these neurons can be studied in vivo has facilitated investigation of several fundamental aspects of neurotrophin biology. Studies of the timing and sequence of action of neurotrophins and the expression of neurotrophins and their receptors in this well characterised neuronal system have led to a detailed understanding of the functions of neurotrophins in neuronal development. The concepts of neurotrophin independent survival, neurotrophin switching and neurotrophin cooperativity have largely arisen from work on the trigeminal system. Moreover, in vitro studies of trigeminal neurons provided some of the first evidence that the neurotrophin requirements of sensory neurons are related to sensory modality. The developing trigeminal system has been studied most extensively in mice and chickens, each of which has particular advantages for understanding different aspects of neurotrophin biology. In this review, I will outline these advantages and describe some of the main findings that have arisen from this work.
在鸟类和哺乳动物胚胎发育的各个阶段，三叉神经系统的初级感觉神经元易于获取，并且这些神经元在体内易于研究，这促进了对神经营养素生物学几个基本方面的研究。对神经营养素作用的时间和顺序以及神经营养素及其受体在这个特征明确的神经元系统中的表达进行研究，已使人们对神经营养素在神经元发育中的功能有了详细的了解。神经营养素非依赖性存活、神经营养素转换和神经营养素协同作用的概念很大程度上源于对三叉神经系统的研究。此外，对三叉神经元的体外研究提供了一些最早的证据，表明感觉神经元对神经营养素的需求与感觉模式有关。发育中的三叉神经系统在小鼠和鸡中得到了最广泛的研究，它们在理解神经营养素生物学的不同方面各有其独特优势。在这篇综述中，我将概述这些优势，并描述这项研究得出的一些主要发现。
