胎鼠下颌髁突软骨发育过程中Ⅱ型和X型胶原蛋白的免疫组织化学及碱性磷酸酶的酶组织化学研究
Immunohistochemistry of collagen types II and X, and enzyme-histochemistry of alkaline phosphatase in the developing condylar cartilage of the fetal mouse mandible.
作者信息
Shibata S, Fukada K, Suzuki S, Yamashita Y
机构信息
1st Department of Oral Anatomy, School of Dentistry, Tokyo Medical and Dental University, Japan.
出版信息
J Anat. 1997 Nov;191 ( Pt 4)(Pt 4):561-70. doi: 10.1046/j.1469-7580.1997.19140561.x.
Abstract
We investigated the immunohistochemical localisation of types II and X collagen as well as the cytochemical localisation of alkaline phosphatase in the developing condylar cartilage of the fetal mouse mandible on d 14-16 of pregnancy. On d 14 of pregnancy, although no immunostaining for types II and X collagen was observed, alkaline phosphatase activity was detected in all cells in the anlage of the future condylar process. On d 15 of pregnancy, immunostaining for both collagen types was simultaneously detected in the primarily formed condylar cartilage. Alkaline phosphatase activity was also detected in chondrocytes at this stage. By d 16 of pregnancy, the hypertrophic cell zone rapidly increased in size. These findings strongly support a periosteal origin for the condylar cartilage of the fetal mouse mandible, and show that progenitor cells for condylar cartilage rapidly or directly differentiate into hypertrophic chondrocytes.
摘要
我们研究了妊娠第14 - 16天胎鼠下颌髁突软骨发育过程中II型和X型胶原蛋白的免疫组织化学定位以及碱性磷酸酶的细胞化学定位。妊娠第14天，虽然未观察到II型和X型胶原蛋白的免疫染色，但在未来髁突原基的所有细胞中检测到碱性磷酸酶活性。妊娠第15天，在初步形成的髁突软骨中同时检测到两种胶原蛋白类型的免疫染色。此阶段软骨细胞中也检测到碱性磷酸酶活性。到妊娠第16天，肥大细胞区迅速增大。这些发现有力地支持了胎鼠下颌髁突软骨起源于骨膜的观点，并表明髁突软骨的祖细胞迅速或直接分化为肥大软骨细胞。
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