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In vitro activity of sanfetrinem and affinity for the penicillin-binding proteins of Streptococcus pneumoniae.三氟沙星的体外活性及其对肺炎链球菌青霉素结合蛋白的亲和力。
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2
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Penicillin-binding proteins in Streptococcus pneumoniae: alterations during development of intrinsic penicillin resistance.肺炎链球菌中的青霉素结合蛋白：固有青霉素耐药性发展过程中的改变
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引用本文的文献

1
Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci.青霉素结合蛋白（PBPs）1a、2b和2x中氨基酸改变对18株青霉素敏感、中介及耐药肺炎链球菌临床分离株中青霉素、氨苄西林、阿莫西林、头孢妥仑、头孢呋辛、头孢丙烯和头孢克洛的PBP亲和力的影响
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2
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本文引用的文献

1
MIC and time-kill studies of antipneumococcal activity of GV 118819X (sanfetrinem) compared with those of other agents.将GV 118819X（三苯菌素）与其他药物的抗肺炎球菌活性进行的最低抑菌浓度（MIC）和杀菌动力学研究。
Antimicrob Agents Chemother. 1997 Jan;41(1):148-55. doi: 10.1128/AAC.41.1.148.
2
In vitro activity of the trinem sanfetrinem (GV104326) against gram-positive organisms.三联抗菌剂sanfetrinem（GV104326）对革兰氏阳性菌的体外活性。
Antimicrob Agents Chemother. 1996 Sep;40(9):2142-6. doi: 10.1128/AAC.40.9.2142.
3
In vitro selection of one-step mutants of Streptococcus pneumoniae resistant to different oral beta-lactam antibiotics is associated with alterations of PBP2x.对不同口服β-内酰胺类抗生素耐药的肺炎链球菌一步突变体的体外筛选与青霉素结合蛋白2x（PBP2x）的改变有关。
Antimicrob Agents Chemother. 1996 Jan;40(1):152-6. doi: 10.1128/AAC.40.1.152.
4
Management of infections caused by antibiotic-resistant Streptococcus pneumoniae.耐抗生素肺炎链球菌所致感染的管理
N Engl J Med. 1994 Aug 11;331(6):377-82. doi: 10.1056/NEJM199408113310607.
5
In vitro activity of the tribactam GV104326 against gram-positive, gram-negative, and anaerobic bacteria.三抗菌GV104326对革兰氏阳性菌、革兰氏阴性菌和厌氧菌的体外活性。
Antimicrob Agents Chemother. 1994 Oct;38(10):2362-8. doi: 10.1128/AAC.38.10.2362.
6
Evaluation of the in-vitro activity of furopenem (SY5555 or SUN5555) against respiratory tract pathogens and beta-lactamase producing bacteria.呋罗培南（SY5555或SUN5555）对呼吸道病原体及产β-内酰胺酶细菌的体外活性评估。
J Antimicrob Chemother. 1995 Apr;35(4):535-9. doi: 10.1093/jac/35.4.535.
7
In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae.β-内酰胺类抗生素与肺炎链球菌青霉素结合蛋白的体内相互作用。
Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. doi: 10.1128/AAC.18.4.629.
8
Inhibition of cell wall synthesis and acylation of the penicillin binding proteins during prolonged exposure of growing Streptococcus pneumoniae to benzylpenicillin.在生长的肺炎链球菌长时间暴露于苄青霉素期间，青霉素结合蛋白的细胞壁合成和酰化受到抑制。
Eur J Biochem. 1985 Sep 16;151(3):475-83. doi: 10.1111/j.1432-1033.1985.tb09126.x.
9
Interaction of non-lytic beta-lactams with penicillin-binding proteins in Streptococcus pneumoniae.非溶菌性β-内酰胺类药物与肺炎链球菌中青霉素结合蛋白的相互作用。
J Gen Microbiol. 1987 Mar;133(3):755-60. doi: 10.1099/00221287-133-3-755.
10
Penicillin-binding proteins and the antibacterial effectiveness of beta-lactam antibiotics.青霉素结合蛋白与β-内酰胺类抗生素的抗菌效力
Rev Infect Dis. 1986 Jul-Aug;8 Suppl 3:S260-78. doi: 10.1093/clinids/8.supplement_3.s260.

三氟沙星的体外活性及其对肺炎链球菌青霉素结合蛋白的亲和力。

In vitro activity of sanfetrinem and affinity for the penicillin-binding proteins of Streptococcus pneumoniae.

作者信息

Sifaoui F, Varon E, Kitzis M D, Gutmann L

机构信息

L.R.M.A., Université Paris VI, France.

出版信息

Antimicrob Agents Chemother. 1998 Jan;42(1):173-5. doi: 10.1128/AAC.42.1.173.

DOI:10.1128/AAC.42.1.173
PMID:9449281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105476/
Abstract

Against penicillin-susceptible pneumococci, the activity of sanfetrinem was similar to those of penicillin, amoxicillin, cefotaxime, imipenem, and meropenem, while against penicillin-resistant strains, sanfetrinem and the carbapenems exhibited superior activity (MICs at which 90% of strains are inhibited, < or =1 microg/ml). PBP 1a in the penicillin-susceptible strain and PBP 1a and PBP 2b in the more resistant isolates seemed to be the essential penicillin-binding proteins for imipenem and sanfetrinem.

摘要

针对对青霉素敏感的肺炎球菌，三唑巴坦的活性与青霉素、阿莫西林、头孢噻肟、亚胺培南和美罗培南相似，而针对耐青霉素菌株，三唑巴坦和碳青霉烯类药物表现出更强的活性（90%菌株被抑制时的最低抑菌浓度，≤1微克/毫升）。对青霉素敏感菌株中的青霉素结合蛋白1a以及耐药性更强的菌株中的青霉素结合蛋白1a和青霉素结合蛋白2b似乎是亚胺培南和三唑巴坦的关键青霉素结合蛋白。