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本文引用的文献

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A beta-lactamase from Serratia marcescens hydrolyzing the 2-carboxypenam T-5575.一种来自粘质沙雷氏菌的β-内酰胺酶，可水解2-羧基青霉烷T-5575。
Antimicrob Agents Chemother. 1995 Sep;39(9):2132-4. doi: 10.1128/AAC.39.9.2132.
2
Plasmid-mediated AmpC-type beta-lactamase isolated from Klebsiella pneumoniae confers resistance to broad-spectrum beta-lactams, including moxalactam.从肺炎克雷伯菌中分离出的质粒介导的AmpC型β-内酰胺酶可赋予对包括莫西沙星在内的广谱β-内酰胺类抗生素的耐药性。
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Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C beta-lactamase gene in Escherichia coli BS.大肠杆菌BS中质粒介导的C类β-内酰胺酶基因blaBIL-1的克隆与序列分析
Antimicrob Agents Chemother. 1994 May;38(5):1182-5. doi: 10.1128/AAC.38.5.1182.
4
Cloning and expression in Enterobacteriaceae of the extended-spectrum beta-lactamase gene from a Pseudomonas aeruginosa plasmid.铜绿假单胞菌质粒中广谱β-内酰胺酶基因在肠杆菌科中的克隆与表达。
FEMS Microbiol Lett. 1994 Aug 15;121(2):175-80. doi: 10.1111/j.1574-6968.1994.tb07096.x.
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Molecular evolution of a class C beta-lactamase extending its substrate specificity.扩展底物特异性的C类β-内酰胺酶的分子进化
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Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variants.肺炎克雷伯菌中FOX-1的基因序列和生化特性，一种具有两种分子变体的新型AmpC型质粒介导的β-内酰胺酶。
Antimicrob Agents Chemother. 1994 Sep;38(9):2150-7. doi: 10.1128/AAC.38.9.2150.
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A functional classification scheme for beta-lactamases and its correlation with molecular structure.β-内酰胺酶的功能分类方案及其与分子结构的相关性。
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8
ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.大肠杆菌K-12的AmpC头孢菌素酶与青霉素酶型β-内酰胺酶有着不同的进化起源。
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9
The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.pUC质粒，一种源自M13mp7的用于插入诱变和使用合成通用引物进行测序的系统。
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10
Sequence of the Citrobacter freundii OS60 chromosomal ampC beta-lactamase gene.弗氏柠檬酸杆菌OS60染色体ampCβ-内酰胺酶基因序列
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来自具有不同底物特异性的粘质沙雷氏菌临床分离株的同源β-内酰胺酶序列。

Sequences of homologous beta-lactamases from clinical isolates of Serratia marcescens with different substrate specificities.

作者信息

Matsumura N, Minami S, Mitsuhashi S

机构信息

Episome Institute, Seta-gun Gunma, Japan.

出版信息

Antimicrob Agents Chemother. 1998 Jan;42(1):176-9. doi: 10.1128/AAC.42.1.176.

DOI:10.1128/AAC.42.1.176
PMID:9449282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105477/
Abstract

Genes for two group 1 beta-lactamases, SRT-1 and SST-1, were sequenced. These beta-lactamases were produced by clinical isolates of Serratia marcescens, isolates GN16694 and GN19450, respectively. The resulting enzymes were 96% identical. SRT-1 hydrolyzed oxyimino cephalosporins, but SST-1 hardly hydrolyzed them. At residue 213 in the third motif, which is conserved among group 1 beta-lactamases, SRT-1 and SST-1 had Lys and Glu, respectively. By site-directed mutagenesis, the substitution of Glu by Lys at residue 213 in SST-1 resulted in an enzyme that hydrolyzed oxyimino cephalosporins.

摘要

对两种1类β-内酰胺酶SRT-1和SST-1的基因进行了测序。这些β-内酰胺酶分别由粘质沙雷氏菌的临床分离株GN16694和GN19450产生。所得的酶有96%的同源性。SRT-1可水解氧亚氨基头孢菌素，但SST-1几乎不能水解它们。在1类β-内酰胺酶中保守的第三个基序的第213位残基处，SRT-1和SST-1分别具有赖氨酸和谷氨酸。通过定点诱变，将SST-1中第213位残基的谷氨酸替换为赖氨酸，产生了一种能够水解氧亚氨基头孢菌素的酶。