转运RNA在核糖体中的移动。
The movement of tRNA through the ribosome.
作者信息
Frank J, Agrawal R K
机构信息
Wadsworth Center, New York State Department of Health, Albany 12201-0509, USA.
出版信息
Biophys J. 1998 Jan;74(1):589-94. doi: 10.1016/S0006-3495(98)77817-8.
Abstract
The interaction between tRNA and the ribosome during translation, specifically during elongation, constitutes an example of the motion and adaptability of living molecules. Recent results obtained by cryoelectron microscopy of "naked" ribosomes and ribosomes in functional binding states shine some light on this fundamental life-sustaining process. Inspection of the surface contour of our reconstruction reveals a precise "lock-and-key" fit between the intersubunit space and the tRNA molecule.
摘要
在翻译过程中，特别是在延伸阶段，tRNA与核糖体之间的相互作用构成了生物分子运动性和适应性的一个例子。通过对“裸露”核糖体和处于功能结合状态的核糖体进行冷冻电子显微镜观察所获得的最新结果，为这一维持生命的基本过程提供了一些线索。对我们重建的表面轮廓进行检查发现，亚基间空间与tRNA分子之间存在精确的“锁钥”适配。
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