Tuominen H, Pöllänen R, Kallioinen M
Department of Pathology, University Hospital of Oulu, Finland.
J Cutan Pathol. 1997 Nov;24(10):590-6. doi: 10.1111/j.1600-0560.1997.tb01089.x.
Tenascin mRNA expression was studied by an in situ hybridization method in 27 skin tumors. Tenascin synthesis was increased in all skin tumors when compared to uninvolved skin but there was variation in the site of cellular synthesis between different types of tumors. In melanocytic nevi and precancerous keratinocyte lesions, tenascin seemed to be of epidermal or stromal origin. In basal cell carcinoma, squamous cell carcinoma and malignant melanoma, there was tenascin synthesis also in tumor cells. These findings are in concordance with earlier studies which suggest a role of tenascin as an anti-adhesive and motility-promoting factor in malignant skin tumors.
采用原位杂交法对27例皮肤肿瘤中的腱生蛋白信使核糖核酸（Tenascin mRNA）表达进行了研究。与未受累皮肤相比，所有皮肤肿瘤中腱生蛋白的合成均增加，但不同类型肿瘤之间细胞合成部位存在差异。在黑素细胞痣和癌前角质形成细胞病变中，腱生蛋白似乎起源于表皮或基质。在基底细胞癌、鳞状细胞癌和恶性黑色素瘤中，肿瘤细胞中也有腱生蛋白的合成。这些发现与早期研究一致，早期研究表明腱生蛋白在恶性皮肤肿瘤中作为抗黏附和促进运动因子发挥作用。
