Ginarte M, García-Caballero T, Fernández-Redondo V, Beiras A, Toribio J
Department of Dermatology, Hospitalario Universitario, Faculty of Medicine, Santiago de Compostela, Spain.
J Cutan Pathol. 2000 Jul;27(6):276-82. doi: 10.1034/j.1600-0560.2000.027006276.x.
The skin has the necessary elements to respond to growth hormone (GH) and suffers clinical changes in the pathological circumstances of excess and deficiency of GH. The GH has been involved in the development of different types of human neoplasms. Based on these data, we have studied the GH receptor (GHR) expression in acrochordons, seborrheic keratosis, melanocytic nevi, histiocytomas, squamous cell carcinomas, basal cell carcinomas, and malignant melanomas by means of the immunohistochemistry with the monoclonal antibody MAb 263. All the entities showed immunoreactivity for GHR. In the histiocytomas, the expression of GHR in the keratinocytes of the hyperplastic epidermis coating the lesion showed a strong nuclear pattern, but the non-hyperplastic epidermis of the edges of the histiocytomas expressed GHR with a cytoplasmic pattern. In the basal cell carcinoma and squamous cell carcinoma, the immunoreactivity was weaker than in normal skin. In the squamous cell carcinoma, the intensity of immunostaining correlated directly with the grade of cellular differentiation. In conclusion, the GH may be involved in the development of different kinds of cutaneous neoplasms, and the intracellular localization of GHR may imply a functional significance, at least in the histiocytomas.
皮肤具备对生长激素（GH）作出反应的必要元素，且在GH分泌过多和过少的病理情况下会出现临床变化。GH已被证实与多种人类肿瘤的发生发展有关。基于这些数据，我们使用单克隆抗体MAb 263通过免疫组织化学方法研究了GH受体（GHR）在软垂疣、脂溢性角化病、黑素细胞痣、组织细胞瘤、鳞状细胞癌、基底细胞癌和恶性黑色素瘤中的表达情况。所有这些病变组织均显示出GHR免疫反应性。在组织细胞瘤中，覆盖病变的增生性表皮角质形成细胞中GHR的表达呈强核型，但组织细胞瘤边缘的非增生性表皮中GHR的表达呈胞质型。在基底细胞癌和鳞状细胞癌中，免疫反应性比正常皮肤弱。在鳞状细胞癌中，免疫染色强度与细胞分化程度直接相关。总之，GH可能参与了不同类型皮肤肿瘤的发生发展，并且GHR的细胞内定位可能具有功能意义，至少在组织细胞瘤中是这样。
