Esposito G, Luparini M R
Aziende Chimiche Riunite Angelini Francesco S.p.A. (ACRAF S.p.A.), Medical Department, Rome, Italy.
Arzneimittelforschung. 1997 Nov;47(11A):1306-9.
Pivagabine (4-[(2,2-dimethyl-1-oxopropyl)amino]butanoic acid, CAS 69542-93-4, Tonerg) is a metabolically stable compound with a modulatory effect on some biochemical parameters involved in stress conditions (corticotropin releasing factor, neurosteroids). The compound, tested in several animal models, prevents stress-correlated behavioural deficits. Moreover, pivagabine has a highly significant therapeutic potential in clinical conditions characterized by manifestations of psychological distress due to an inadequate management of stressful events.
匹伐加滨（4-[(2,2-二甲基-1-氧代丙基)氨基]丁酸，化学物质登记号69542-93-4，托纳格）是一种代谢稳定的化合物，对参与应激状态的某些生化参数（促肾上腺皮质激素释放因子、神经甾体）具有调节作用。该化合物在多种动物模型中进行了测试，可预防与应激相关的行为缺陷。此外，匹伐加滨在因应激事件管理不当而出现心理困扰表现的临床病症中具有极高的治疗潜力。
