Eckstein F, Jacobs C R, Merz B R
Ludwig Maximilians Universität München, Germany.
Med Eng Phys. 1997 Dec;19(8):720-8. doi: 10.1016/s1350-4533(97)00031-3.
Computed tomography (CT) has been employed to determine non-invasively the distribution of subchondral bone density in joints and to evaluate their dominant loading pattern. The objective of this study was to investigate the relationship between subchondral bone adaptation, joint incongruity and loading, in order to determine to what extent the loading conditions and/or geometric configuration can be inferred from the distribution of subchondral density. Finite element models of joints with various degrees of incongruity were designed and a current remodeling theory implemented using the node-based approach. Appropriate combinations of joint incongruity and loading yielded subchondral bone density patterns consistent with experimental findings, specifically a bicentric distribution in the humero-ulnar joint and a monocentric distribution in the humero-radial joint. However, other combinations of incongruity and loading produced similar subchondral density patterns. Both the geometric joint configuration and the loading conditions influence the distribution of subchondral density in such a way that one of these factors must be known a priori to estimate the other. Since subchondral density can be assessed by CT and joint geometry by magnetic resonance imaging, the dominant loading pattern of joints may be potentially derived in the living using these non-invasive imaging methods.
计算机断层扫描（CT）已被用于非侵入性地确定关节软骨下骨密度的分布，并评估其主要载荷模式。本研究的目的是调查软骨下骨适应性、关节不协调与载荷之间的关系，以确定从软骨下密度分布中可以推断出载荷条件和/或几何构型的程度。设计了具有不同程度不协调的关节有限元模型，并使用基于节点的方法实施了当前的重塑理论。关节不协调和载荷的适当组合产生了与实验结果一致的软骨下骨密度模式，特别是在肱尺关节中的双中心分布和在肱桡关节中的单中心分布。然而，不协调和载荷的其他组合产生了类似的软骨下密度模式。关节的几何构型和载荷条件都会影响软骨下密度的分布，以至于必须先验地知道其中一个因素才能估计另一个因素。由于软骨下密度可以通过CT评估，关节几何形状可以通过磁共振成像评估，因此使用这些非侵入性成像方法可能在活体中得出关节的主要载荷模式。
