Ghio A J, Taylor D E, Stonehuerner J G, Piantadosi C A, Crumbliss A L
Department of Medicine, Duke University, Durham, NC 27708-0346, USA.
Biometals. 1998 Jan;11(1):41-7. doi: 10.1023/a:1009257323963.
Treatment of aqueous suspensions of different asbestos fibers (amosite, anthophyllite, chrysotile, and crocidolite) at 0-4 degrees C and pH 7.2 with H2O2 results in the consumption of H2O2 with concomitant release of iron and production of O2. During incubations, [H2O2] decreased in proportion to the mass of the suspended fiber, the duration of incubation, and the initial [H2O2]. The consumption of H2O2, production of O2 and release of iron all vary synergistically with the structure of the asbestos fiber. Release of silicon during the incubation was small relative to the decrement in [H2O2], reflecting a lack of dissolution of the fiber. The data are consistent with a redox process for the release of surface bound iron and it is significant that iron release occurs in the absence of a Fe(II) or Fe(III) chelator. The implications of iron release from the asbestos surface may be important in inflammatory disorders in which both silicate bound iron and H2O2 accumulate.
在0 - 4摄氏度和pH值为7.2的条件下，用过氧化氢处理不同石棉纤维（铁石棉、直闪石、温石棉和青石棉）的水悬浮液，会导致过氧化氢的消耗，同时伴随着铁的释放和氧气的产生。在孵育过程中，过氧化氢的浓度与悬浮纤维的质量、孵育时间以及初始过氧化氢浓度成比例下降。过氧化氢的消耗、氧气的产生和铁的释放都与石棉纤维的结构协同变化。孵育过程中硅的释放相对于过氧化氢浓度的降低较少，这反映出纤维没有溶解。这些数据与表面结合铁释放的氧化还原过程一致，并且重要的是铁的释放在没有亚铁或铁离子螯合剂的情况下发生。石棉表面铁释放的影响在炎症性疾病中可能很重要，在这些疾病中硅酸盐结合的铁和过氧化氢都会积累。
