Moriguchi S, Kato M, Sakai K, Yamamoto S, Shimizu E
Department of Nutrition, School of Medicine, The University of Tokushima, Japan.
J Appl Physiol (1985). 1998 Jan;84(1):311-7. doi: 10.1152/jappl.1998.84.1.311.
This study investigated whether exercise training had a beneficial effect on the decreased mitogen response and improved a decreased expression of glucose transporter 1 (GLUT-1) in splenocytes from obese Zucker rats. Experimental groups were lean and sedentary and exercise-trained obese Zucker rats. Exercise training, running on a motor-driven treadmill for 5 days/wk for 40 wk, did not induce a significant decrease in body weight in obese Zucker rats. The plasma insulin concentration, showing a significant increase compared with lean Zucker rats, was unaffected by exercise training. However, the plasma triglyceride concentration in obese Zucker rats was significantly depressed by exercise training, whereas it was still higher than that in lean Zucker rats. In addition, natural killer cell activity and concanavalin A-induced mitogenesis of splenic lymphocytes of obese Zucker rats were significantly restored. In these splenic lymphocytes, glucose uptake was significantly lower compared with that in lean Zucker rats, which was also improved by exercise training. Although the expression of GLUT-1, the major glucose transporter in immune cells, was depressed in splenic lymphocytes of obese Zucker rats, exercise training induced a significant improvement. These results suggest that exercise training has a beneficial effect on the decreased cellular immune functions in obese Zucker rats, which is associated, in part, with the improvement in GLUT-1 expression.
本研究调查了运动训练对肥胖Zucker大鼠脾细胞中促分裂原反应降低以及葡萄糖转运蛋白1（GLUT-1）表达下降是否具有有益作用。实验组包括瘦的久坐不动的大鼠以及经过运动训练的肥胖Zucker大鼠。运动训练是在电动跑步机上每周跑5天，持续40周，这并未使肥胖Zucker大鼠的体重显著下降。与瘦的Zucker大鼠相比，血浆胰岛素浓度显著升高，运动训练对其没有影响。然而，运动训练使肥胖Zucker大鼠的血浆甘油三酯浓度显著降低，但其仍高于瘦的Zucker大鼠。此外，肥胖Zucker大鼠脾淋巴细胞的自然杀伤细胞活性和伴刀豆球蛋白A诱导的有丝分裂显著恢复。在这些脾淋巴细胞中，与瘦的Zucker大鼠相比，葡萄糖摄取显著降低，运动训练也使其得到改善。尽管肥胖Zucker大鼠脾淋巴细胞中免疫细胞的主要葡萄糖转运蛋白GLUT-1的表达降低，但运动训练使其显著改善。这些结果表明，运动训练对肥胖Zucker大鼠降低的细胞免疫功能具有有益作用，这部分与GLUT-1表达的改善有关。
