Friedman J E, Sherman W M, Reed M J, Elton C W, Dohm G L
Department of Biochemistry, School of Medicine, East Carolina University, Greenville 27858-4354.
FEBS Lett. 1990 Jul 30;268(1):13-6. doi: 10.1016/0014-5793(90)80960-q.
The present study examined the level of GLUT-4 glucose transporter protein in gastrocnemius muscles of 36 week old genetically obese Zucker (fa/fa) rats and their lean (Fa/-) littermates, and in obese Zucker rats following 18 or 30 weeks of treadmill exercise training. Despite skeletal muscle insulin resistance, the level of GLUT-4 glucose transporter protein was similar in lean and obese Zucker rats. In contrast, exercise training increased GLUT-4 protein levels by 1.7 and 2.3 fold above sedentary obese rats. These findings suggest endurance training stimulates expression of skeletal muscle GLUT-4 protein which may be responsible for the previously observed increase in insulin sensitivity with training.
本研究检测了36周龄遗传性肥胖的Zucker（fa/fa）大鼠及其瘦型（Fa/-）同窝仔鼠腓肠肌中葡萄糖转运蛋白4（GLUT-4）的水平，并检测了18周或30周跑步机运动训练后肥胖Zucker大鼠腓肠肌中GLUT-4的水平。尽管存在骨骼肌胰岛素抵抗，但瘦型和肥胖Zucker大鼠的GLUT-4葡萄糖转运蛋白水平相似。相比之下，运动训练使GLUT-4蛋白水平比久坐不动的肥胖大鼠分别增加了1.7倍和2.3倍。这些发现表明，耐力训练可刺激骨骼肌GLUT-4蛋白的表达，这可能是之前观察到的训练后胰岛素敏感性增加的原因。
