Aboulafia D M
Section of Hematology/Oncology, Virginia Mason Medical Center, Seattle, Washington 98111, USA.
J Clin Gastroenterol. 1997 Dec;25(4):640-5. doi: 10.1097/00004836-199712000-00018.
Pancreatic disease in patients with AIDS often is so mild that the diagnosis may be missed. The pancreas can be affected by systemic illness caused by opportunistic infections, Kaposi's sarcoma, or lymphoma. More commonly, drugs used to treat patients infected with human immunodeficiency virus can cause pancreatitis and result in significant morbidity and, rarely, mortality. We report one such case in a 47-year-old patient with AIDS in whom pancreatitis developed while taking 2',3'-dideoxyinosine (ddI). His condition improved on ddI withdrawal, but he suffered a fatal relapse while receiving 2',3'-dideoxycytidine and trimethoprim-sulfamethoxazole. This case gives me the opportunity to review the literature regarding the incidence, causes, and diagnosis of human immunodeficiency virus-associated pancreatitis.
艾滋病患者的胰腺疾病通常很轻微，以至于可能会漏诊。胰腺可受到由机会性感染、卡波西肉瘤或淋巴瘤引起的全身性疾病影响。更常见的是，用于治疗人类免疫缺陷病毒感染患者的药物可导致胰腺炎，并造成显著的发病率，很少导致死亡。我们报告了一名47岁艾滋病患者的此类病例，该患者在服用2',3'-双脱氧肌苷（ddI）时发生了胰腺炎。停用ddI后他的病情有所改善，但在接受2',3'-双脱氧胞苷和甲氧苄啶-磺胺甲恶唑治疗时病情致命复发。这个病例让我有机会回顾关于人类免疫缺陷病毒相关胰腺炎的发病率、病因和诊断的文献。
