[在哥廷根小型猪中进行无应激麻醉诱导ZESTRANI（零应激麻醉诱导）。一种实验方法]

[Stress free anesthesia induction ZESTRANI (ZEro STRess ANesthesia Induction) in Göttingen minipigs. An experimental method].

作者信息

Petroianu G A, Altmannsberger S H, Maleck W, Jatzko A, Rüfer R

机构信息

Institut für Pharmakologie und Toxikologie, Fakultät für Klinische Medizin Mannheim, Ruprecht-Karls-Universität Heidelberg.

出版信息

Tierarztl Prax Ausg G Grosstiere Nutztiere. 1997 Nov;25(6):587-93.

PMID:9451763

Abstract

The Göttingen Mini-pig is a popular laboratory animal, that is used i.a. in experimental surgery and anaesthesia. For ethical and scientific reasons it is mandatory to minimize the stress the laboratory animals are exposed to. The presented stress-free experimental anaesthesia induction (ZESTRANI) is based on innovative means to achieve adequate analgesia using different substances appropriate for the animal's state of consciousness. Markedly lower heart rates and mean arterial pressures are seen when the ZESTRANI-method is used as compared retrospectively to the previously used "conventional" anaesthesia induction. With the ZESTRANI method no "fight or flight"-reactions are seen.

摘要

哥廷根小型猪是一种常用的实验动物，常用于实验外科手术和麻醉。出于伦理和科学原因，必须将实验动物所承受的压力降至最低。所提出的无应激实验性麻醉诱导法（ZESTRANI）基于创新手段，利用适合动物意识状态的不同物质实现充分镇痛。与之前使用的“传统”麻醉诱导法相比，回顾性观察发现，使用ZESTRANI法时心率和平均动脉压明显更低。采用ZESTRANI法时未观察到“战斗或逃跑”反应。