Siever D A, Erickson H P
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Int J Biochem Cell Biol. 1997 Nov;29(11):1219-23. doi: 10.1016/s1357-2725(97)00057-5.
Annexin II belongs to a family of calcium-dependent, phospholipid binding proteins. Annexin II was first identified as an intracellular protein and attributed intracellular functions. Although it lacks a signal peptide and its mechanism of secretion is unknown, extracellular annexin II has recently been found in several tissues as both soluble and membrane-bound protein. Cell-surface annexin II has been identified as a receptor for a number of polypeptide ligands. Extracellular annexin II may be important in several biological processes, such as fibrinolysis, cell adhesion, ligand-mediated cell signaling and virus infection. These processes provide several possibilities for therapeutic approaches targeting extracellular annexin II, and future research should further illuminate the biology of this molecule.
膜联蛋白II属于一类钙依赖性磷脂结合蛋白家族。膜联蛋白II最初被鉴定为一种细胞内蛋白，并被认为具有细胞内功能。尽管它缺乏信号肽且其分泌机制尚不清楚，但最近在多种组织中发现细胞外膜联蛋白II以可溶性和膜结合蛋白两种形式存在。细胞表面的膜联蛋白II已被确定为多种多肽配体的受体。细胞外膜联蛋白II可能在多种生物学过程中起重要作用，如纤维蛋白溶解、细胞黏附、配体介导的细胞信号传导和病毒感染。这些过程为针对细胞外膜联蛋白II的治疗方法提供了多种可能性，未来的研究应进一步阐明该分子的生物学特性。
