Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.
Exp Hematol. 2012 Sep;40(9):685-94. doi: 10.1016/j.exphem.2012.05.004. Epub 2012 May 26.
Blood and bone are dynamic tissues that are continuously renewed throughout life. Early observations based upon the proximity of bone and hematopoietic progenitor populations in marrow suggested that interactions between skeletal and hematopoietic elements are likely to be crucial in the development and function of each system. As a result of these morphologic observations, several groups have demonstrated that the osteoblasts play an important role in hematopoiesis by serving as a specific local microenvironment, or niche, for hematopoietic stem cells. Significant new developments in this area of active investigation have emerged since our last examination of this area in 2005. Here we discuss these new insights into the function and morphology of the hematopoietic stem cell niche, with a particular focus on cells of the osteoblastic lineage.
血液和骨骼是不断更新的动态组织。早期的观察基于骨髓中骨骼和造血祖细胞群体的接近程度，表明骨骼和造血成分之间的相互作用可能对每个系统的发育和功能都至关重要。由于这些形态学观察，一些研究小组已经证明，成骨细胞通过充当造血干细胞的特定局部微环境或龛位，在造血中发挥重要作用。自 2005 年我们上次检查该领域以来，该领域的活跃研究出现了一些重大的新进展。在这里，我们讨论这些关于造血干细胞龛位的功能和形态的新见解，特别关注成骨细胞谱系的细胞。
