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Pleuromutilins. Fermentation, structure and biosynthesis.

作者信息

Knauseder F, Brandl E

出版信息

J Antibiot (Tokyo). 1976 Feb;29(2):125-31. doi: 10.7164/antibiotics.29.125.

DOI:10.7164/antibiotics.29.125
PMID:945258
Abstract

Derivatives of pleuromutilin, formed during the fermentation of pleuromutilin, were isolated and their structure determined. 14-Acetyl-mutilin and mutilin as well as different unsaturated fatty acid esters of pleuromutilin were identified. The proportion of each derivative formed depends to a considerable degree on the conditions of the fermentation process. The possible biosynthetic pathways are shown.

摘要

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