Egger H, Reinshagen H
J Antibiot (Tokyo). 1976 Sep;29(9):915-22. doi: 10.7164/antibiotics.29.915.
A series of new derivatives of the antibiotic pleuromutilin, produced by some Basidiomycetes, was synthesized by chemical modification of natural pleuromutilin. Most of them contain basic functional groups in the side chain at C14 of the mutilin skeleton. The monotosylate of pleuromutilin was used as a versatile intermediate for displacement by N-, O- and S-nucleophiles.
通过对天然截短侧耳素进行化学修饰，合成了一系列由某些担子菌产生的抗生素截短侧耳素的新衍生物。它们中的大多数在截短侧耳素骨架的C14侧链上含有碱性官能团。截短侧耳素的单对甲苯磺酸盐用作N-、O-和S-亲核试剂取代反应的通用中间体。
