Gacon G, Laurencon M, Van de Velde D, Giudicelli D P
Clinique du Parc, Lyon.
Rev Chir Orthop Reparatrice Appar Mot. 1997;83(4):313-23.
The purpose of this work was to precise diagnosis and treatment of infected total knee arthroplasty with two stage reimplantation.
29 infected total knee arthroplasties were operated between 1984 and 1994 and included in this study (mean F.U. 3.5 Y). There were 20 females and 9 males, mean age 70 (46-83). The original arthroplasty was done for OA in 28 patients, RA in one. The arthroplasties were: UHK 2, Bicompartmental 2, Tricompartmental 19. 20 TKA were cementless. 14 patients showed one or several risk factors. Infection was diagnosed in 1 of 2 ways: preoperative aspiration or culture of surgical specimen. There were 12 staphylococcus epidermidis, 8 staphylococcus aureus, streptococcus (n = 2) acinetobacter (n = 2), peptococcus (n = 1) pseudomonas (n = 1), gemella morbidellum (n = 1). 6 were non identified.
The protocol for two stage reimplantation began with components and cement removal. A synovectomy was performed. The knee cavity was filled with antibiotic cement spacer and the wound was closed. The leg was placed in a splint. All patients underwend a continued antibiotic therapy, specific in 20 cases with isolated organisms. A total knee arthroplasty was performed, using a total posterior cruciate substituting prosthesis, 6 to 8 weeks after components removal (2-24). All patients received parenteral antibiotics after reimplantation for not less than 2 months (2-6).
Infection was eradicated in 24 cases, 22 in one time, 2 bad second debridement. At last follow-up the average Hungerford score was 75.6/100, the average Knee society knee score was 80 and the average functional score was 70. Mean range of flexion was 95 degrees. 6 patients had recurrent infection and poor result. They underwent arthrodesis. 5 of the 6 patients had solid mature fusion at last follow-up.
The results of two stage reimplantation for infected total knee replacement showed that this is the method of choice for infection treatment and acceptable function restoration. As other authors, we get a good success rate (82 per cent). Functional result was better with identified microorganisms, but we did not find any correlation with organisms type or infection length. Punction and bone scanning are of great help for diagnosis in difficult chronical cases. Organism identification is fundamental for infection duration. Staphylococcus epidermidis was the most frequent identified organism. New procedures using articulated cement spacer may improve functional results.
本研究旨在探讨两期翻修术对感染性全膝关节置换术的精确诊断及治疗。
1984年至1994年间,29例感染性全膝关节置换术患者纳入本研究(平均随访3.5年)。其中女性20例,男性9例,平均年龄70岁(46 - 83岁)。28例患者因骨关节炎行初次置换术,1例因类风湿关节炎。置换类型包括:UHK型2例,双髁型2例,三髁型19例。20例为非骨水泥型。14例患者存在一项或多项危险因素。感染通过两种方式诊断:术前穿刺或手术标本培养。病原菌包括:表皮葡萄球菌12例,金黄色葡萄球菌8例,链球菌2例,不动杆菌2例,消化球菌1例,铜绿假单胞菌1例,龋齿罗氏菌1例。6例病原菌未明确。
两期翻修术首先取出假体及骨水泥,行滑膜切除术,膝关节腔内填充抗生素骨水泥间隔物,关闭伤口,患肢用夹板固定。所有患者持续接受抗生素治疗,20例针对分离出的病原菌使用特异性抗生素。取出假体6至8周后(2 - 24周),使用全后交叉韧带替代假体行全膝关节置换术。所有患者翻修术后接受静脉抗生素治疗不少于2个月(2 - 6个月)。
24例感染得到根除,22例一次根除,2例二次清创效果不佳。末次随访时,平均Hungerford评分为75.6/100,平均膝关节协会膝关节评分为80分,平均功能评分为70分。平均屈曲范围为95度。6例患者感染复发,效果不佳,接受了关节融合术。6例患者中5例在末次随访时获得牢固成熟的融合。
两期翻修术治疗感染性全膝关节置换术的结果表明,这是治疗感染及恢复功能的首选方法。与其他作者一样,我们取得了较高的成功率(82%)。明确病原菌时功能结果更佳,但未发现与病原菌类型或感染时间存在相关性。穿刺及骨扫描对疑难慢性病例的诊断有很大帮助。病原菌鉴定对确定感染持续时间至关重要。表皮葡萄球菌是最常见的病原菌。使用可活动的骨水泥间隔物的新方法可能改善功能结果。