3rd Orthopaedics and Traumatology Clinic, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Arch Orthop Trauma Surg. 2010 Jun;130(6):719-25. doi: 10.1007/s00402-010-1054-y. Epub 2010 Feb 9.
The treatment of infected total knee arthroplasty (TKA) is controversial and various. Two-stage prolonged reimplantation and 6-week systemic antibiotics use have been a gold standard of treatment in recent years.
Seventeen knees of 17 patients, who underwent primary TKA and subsequently developed infections, were implanted articulating antibiotic-loaded cement spacer through two-stage reimplantation. In the postoperative period, parenteral antibiotic treatment targeting the specific microorganism detected in each patient was started and continued with oral administration. The mean total (parenteral and oral) antibiotic treatment time was 6.8 weeks (6-10). The spacer remained in its location until complete soft tissue recovery and normal values for laboratory parameters were achieved. The mean time interval between spacer implantation and reimplantation was 4.2 months (3-6).
In the last follow-up examinations of the patients, conditions requiring reoperation were detected in 3 patients (17.6%). In 2 of these patients (11.7%), infection developed after a mean 1-year interval. The joint motion ranges of the patients were measured in the preoperative period, during spacer use, and following reimplantation. The mean joint motion range of the patients was 58 degrees (12-90) in the preoperative period; in the presence of spacer between the two stages, 69 degrees (15-100); and in the last follow-up examination after reimplantation, 95 degrees (10-120).
Use of articulating cement spacer in the treatment of infected TKA is efficient and reliable.
感染性全膝关节置换术(TKA)的治疗存在争议,方法多样。近年来,两阶段延长再植入和 6 周系统抗生素使用一直是治疗的金标准。
17 名患者的 17 个膝关节在初次 TKA 后发生感染,通过两阶段再植入植入了带抗生素的可活动水泥间隔器。在术后期间,针对每位患者检测到的特定微生物开始进行全身抗生素治疗,并继续口服。平均总(静脉和口服)抗生素治疗时间为 6.8 周(6-10 周)。间隔器保持在原位,直到软组织完全恢复且实验室参数值正常。间隔器植入和再植入之间的平均时间间隔为 4.2 个月(3-6 个月)。
在患者的最后随访检查中,发现 3 名患者(17.6%)需要再次手术。在这 2 名患者(11.7%)中,在平均 1 年的间隔后发生了感染。在术前、使用间隔器和再植入期间测量了患者的关节运动范围。患者的平均关节运动范围为术前 58 度(12-90 度);在两阶段之间存在间隔器时为 69 度(15-100 度);在再植入后的最后随访检查中为 95 度(10-120 度)。
在感染性 TKA 的治疗中使用可活动水泥间隔器是有效和可靠的。