伴有12号染色体短臂等臂染色体的松果体未成熟畸胎瘤。

Immature teratoma of the pineal gland with isochromosome 12p.

作者信息

Dal Cin P, Dei Tos A P, Qi H, Giannini C, Furlanetto A, Longatti P L, Marynen P, Van den Berghe H

机构信息

Center for Human Genetics, University of Leuven, Belgium.

出版信息

Acta Neuropathol. 1998 Jan;95(1):107-10. doi: 10.1007/s004010050772.

DOI:10.1007/s004010050772

PMID:9452829

Abstract

An immature teratoma arising in the pineal gland in a 27-year-old male was shown to present an isochromosome 12p as evidenced by cytogenetic and fluorescence in situ hybridization analysis. As i(12p) is characteristic of gonadal germ cell tumors, this case indicates that similar genetic pathways may operate in gonadal and intracranial teratomas.

摘要

一名27岁男性松果体出现的未成熟畸胎瘤经细胞遗传学和荧光原位杂交分析证实存在12号染色体短臂等臂染色体。由于12号染色体短臂等臂染色体（i(12p)）是性腺生殖细胞肿瘤的特征，该病例表明性腺和颅内畸胎瘤可能存在相似的遗传途径。