Dal Cin P, Dei Tos A P, Qi H, Giannini C, Furlanetto A, Longatti P L, Marynen P, Van den Berghe H
Center for Human Genetics, University of Leuven, Belgium.
Acta Neuropathol. 1998 Jan;95(1):107-10. doi: 10.1007/s004010050772.
An immature teratoma arising in the pineal gland in a 27-year-old male was shown to present an isochromosome 12p as evidenced by cytogenetic and fluorescence in situ hybridization analysis. As i(12p) is characteristic of gonadal germ cell tumors, this case indicates that similar genetic pathways may operate in gonadal and intracranial teratomas.
一名27岁男性松果体出现的未成熟畸胎瘤经细胞遗传学和荧光原位杂交分析证实存在12号染色体短臂等臂染色体。由于12号染色体短臂等臂染色体（i(12p)）是性腺生殖细胞肿瘤的特征，该病例表明性腺和颅内畸胎瘤可能存在相似的遗传途径。
