Lemos J A, Barbieri-Neto J, Casartelli C
Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brazil.
Cancer Genet Cytogenet. 1998 Jan 15;100(2):124-8. doi: 10.1016/s0165-4608(97)00200-8.
Primary intracranial germ cell tumors are the result of the transformation of primordial cells that are unable to migrate to their normal place. These tumors are rare, accounting for less than 5% of all intracranial tumors and less than 3% of childhood neoplasias. In this paper, we have studied cytogenetically two primary intracranial germ cell tumors, a pineal region germinoma, and a mature teratoma in the right lateral ventricle. Neither tumor presented polyploidy or isochromosome 12p, considered to be characteristic of gonadal germ cell tumors. In the five reports in the literature, only one intracranial germ cell tumor presented i(12p). Perhaps i(12p) negative cases characterize a subtype of germ cell tumors.
原发性颅内生殖细胞肿瘤是原始细胞无法迁移到正常位置而发生转化的结果。这些肿瘤很罕见，占所有颅内肿瘤的比例不到5%，占儿童肿瘤的比例不到3%。在本文中，我们对两个原发性颅内生殖细胞肿瘤进行了细胞遗传学研究，一个是松果体区生殖细胞瘤，另一个是右侧侧脑室的成熟畸胎瘤。这两个肿瘤均未出现多倍体或12号染色体短臂等臂染色体，而这些被认为是性腺生殖细胞肿瘤的特征。在文献中的五篇报道中，只有一例颅内生殖细胞肿瘤出现了12号染色体短臂等臂染色体。也许12号染色体短臂等臂染色体阴性的病例代表了生殖细胞肿瘤的一种亚型。
