Cervoni J P, Degos F, Marcellin P, Erlinger S
Unité de Recherches de Physiopathologie Hépatique (INSERM U 24) Hôpital Beaujon, Clichy, France.
J Hepatol. 1997 Dec;27(6):1113-6. doi: 10.1016/s0168-8278(97)80157-2.
We describe the cases of two patients with chronic hepatitis C who developed acute hepatitis with marked amino-transferase elevations and jaundice 3 and 5 months after initiation of interferon treatment. Hepatitis resolved rapidly after cessation of interferon. No autoantibodies were detected. Hepatitis was followed by viral clearance, demonstrated by clearance of hepatitis C viraemia. We propose that hepatitis may be due to an immune lysis of hepatocytes and suggest that this immune response may contribute to viral clearance.
我们描述了两名慢性丙型肝炎患者的病例，他们在开始干扰素治疗3个月和5个月后出现急性肝炎，伴有显著的转氨酶升高和黄疸。停用干扰素后肝炎迅速消退。未检测到自身抗体。肝炎之后出现病毒清除，丙型肝炎病毒血症清除证明了这一点。我们认为肝炎可能是由于肝细胞的免疫溶解，并表明这种免疫反应可能有助于病毒清除。
