Peters J L, Michael A C
Department of Chemistry, University of Pittsburgh, Pennsylvania 15260, USA.
J Neurochem. 1998 Feb;70(2):594-603. doi: 10.1046/j.1471-4159.1998.70020594.x.
Numerical modeling was used as a means to examine the relationship between the outcome of in vivo voltammetry and microdialysis experiments and dopamine concentrations in the extracellular fluid of rat striatum. In the case of microdialysis, quantitative interpretation of results demands knowledge of the in vivo values for the extraction and recovery ratios of the probes toward dopamine. Equality of the extraction and recovery ratios is a necessary condition for the direct application of the no-net-flux method as a quantitative technique. Recent results have suggested that the extraction and recovery ratios are not equal, and this interpretation is now supported by theory. A new relationship between extraction and recovery is proposed.
数值模拟被用作一种手段，以研究体内伏安法和微透析实验的结果与大鼠纹状体细胞外液中多巴胺浓度之间的关系。在微透析的情况下，对结果进行定量解释需要了解探针对于多巴胺的提取率和回收率的体内值。提取率和回收率相等是无净通量法作为一种定量技术直接应用的必要条件。最近的结果表明提取率和回收率并不相等，并且这一解释现在得到了理论的支持。提出了一种提取率和回收率之间的新关系。
