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[耐多药肺炎球菌的应对方案。医生有时会忽视强制通报规定]

[A handling program for resistant pneumococci. Physicians sometimes neglect mandatory notification].

作者信息

Hedlund J, Olsson-Liljequist B

机构信息

Infektionskliniken, Danderyds sjukhus.

出版信息

Lakartidningen. 1997 Dec 17;94(51-52):4914-8.

PMID:9454013
Abstract

Streptococcus pneumoniae infections belong to the leading worldwide causes of illness and death among young children, people with underlying debilitating medical conditions, and the elderly. Following early documentation of infections due to pneumococcal strains with reduced penicillin susceptibility in Australia in 1967, and of infections due to penicillin-resistant strains in South Africa in 1978, pneumococcal resistance to penicillin and other antibiotics has progressed rapidly and is now a global problem. In Sweden, notification of the occurrence of pneumococci with a minimum inhibitory concentration (MIC) > or = 0.5 mg/L for penicillin G (PcG) has been mandatory for general practitioners (GPs) and clinical microbiological laboratories since 1 January 1996. In 1996, 1,057 cases of infection by such pneumococci were reported by microbiological laboratories, but only 262 cases by GPs. With a view to minimising the impact of pneumococci with reduced penicillin susceptibility in Sweden, the National Board of Health and Welfare set up a working group of experts in November 1994. To reduce the transmission of such bacteria in the community, the working group introduced a control programme which includes the isolation of day-care children under six years of age carrying pneumococci with PcG-MICs > or = 0.5 mg/L. An enquiry among the 25 regional centres for infectious disease control in the country to ascertain compliance in the different counties of Sweden showed the programme to have been adhered to in a majority of counties, although many had chosen alternative measures to deal with the problem.

摘要

肺炎链球菌感染是全球幼儿、患有基础衰弱性疾病的人群以及老年人发病和死亡的主要原因之一。1967年澳大利亚首次记录到对青霉素敏感性降低的肺炎球菌菌株引起的感染,1978年南非记录到耐青霉素菌株引起的感染,此后,肺炎球菌对青霉素和其他抗生素的耐药性迅速发展,现已成为一个全球性问题。自1996年1月1日起,瑞典要求全科医生(GP)和临床微生物实验室必须通报青霉素G(PcG)最低抑菌浓度(MIC)≥0.5mg/L的肺炎球菌的发生情况。1996年,微生物实验室报告了1057例此类肺炎球菌感染病例,但全科医生仅报告了262例。为尽量减少瑞典青霉素敏感性降低的肺炎球菌的影响,国家卫生和福利委员会于1994年11月成立了一个专家工作组。为减少此类细菌在社区中的传播,该工作组推出了一项控制计划,其中包括隔离携带PcG-MIC≥0.5mg/L肺炎球菌的6岁以下日托儿童。对该国25个区域传染病控制中心进行的一项调查,以确定瑞典不同县的遵守情况,结果显示,大多数县都遵守了该计划,尽管许多县选择了其他措施来应对这一问题。

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