Brown T P, Garcia A, Kelly L
Department of Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
Avian Dis. 1997 Oct-Dec;41(4):906-9.
Spiking mortality of turkeys (SMT) is an infectious disease of 5-to-25-day-old turkey poults characterized by acute enteritis and bursal and thymic atrophy. It is reproducible by exposure to organ homogenates or contaminated litter. We studied methods potentially useful for decontamination of turkey houses contaminated with SMT. Organ homogenates capable of producing SMT and containing turkey intestinal coronavirus were exposed in vitro for 5 hr to either 5.0% NaCl, pH 2.0, pH 12, 1.0% formaldehyde, 57 C, or lyophilization. Results were assessed by oral gavage of treated inocula into 1-day-old turkeys and measurement of subsequent coronavirus shedding, growth rate, feed conversion, and mortality from 1 to 21 days of age. Formaldehyde treatment rendered the inoculum nonpathogenic, whereas other treatments failed to ameliorate its negative effects.
火鸡尖峰死亡综合征（SMT）是一种发生于5至25日龄火鸡雏的传染病，其特征为急性肠炎以及法氏囊和胸腺萎缩。通过接触器官匀浆或受污染垫料可引发该病。我们研究了对受SMT污染的火鸡舍进行净化可能有用的方法。将能够引发SMT且含有火鸡肠道冠状病毒的器官匀浆在体外分别暴露于5.0%氯化钠、pH 2.0、pH 12、1.0%甲醛、57℃或冻干处理5小时。通过将经处理的接种物经口灌喂给1日龄火鸡，并测量随后1至21日龄期间的冠状病毒排出量、生长速率、饲料转化率和死亡率来评估结果。甲醛处理使接种物失去致病性，而其他处理未能改善其负面影响。
