Itoh S, Iwata A, Watanabe Y, Kitano S, Imai S, Yoshiya K
Division of Radiology, Daiyukai General Hospital.
Kaku Igaku. 1997 Nov;34(11):1047-53.
We measured regional cerebral blood flow before and after acetazolamide administration using a serial noninvasive method with 99mTc-ECD developed by Matsuda and Takeuchi et al., and compared the accuracy of measured values with those obtained by the conventional 123I-IMP ARG method. When the regional cerebral blood flow was measured for 80 brain regions in 5 subjects without scatter correction, a differential of 0.5 +/- 8.4% was obtained between values measured before and after physiological saline administration as a placebo. A differential of -0.2 +/- 12.6% was obtained when the same regions were measured with scatter correction. These findings indicated that placebo administration did not affect measured values, regardless of whether scatter correction was performed. When 64 regions in 4 subjects at rest were measured on two successive days, a differential of -1.1 +/- 9.0% was obtained between the values measured on the two days. A differential of -4.0 +/- 11.7% was obtained for the same regions following acetazolamide administration. These findings showed that measurements were reproducible both when subjects were at rest and when they were administered acetazolamide. The above two methods were used for measurement of 80 brain regions in the same 5 subjects for comparison. Measurements of subjects at rest and with acetazolamide administration were performed on separate days. The regression line y = 0.99x + 1.47, r = 0.80, was obtained for the subjects at rest, and y = 0.86x + 7.76, with r = 0.76, for the subjects following acetazolamide administration. These findings demonstrated a good correlation between the values obtained using the two methods. The values obtained using the method of Matsuda and Takeuchi et al., before and after acetazolamide administration were thus consistent with those reported previously using the conventional method, and the former method proved to be both simple and reliable.
我们采用松田和竹内等人开发的99mTc - ECD连续无创方法，在乙酰唑胺给药前后测量局部脑血流量，并将测量值的准确性与传统的123I - IMP ARG方法获得的测量值进行比较。在5名受试者的80个脑区测量局部脑血流量且不进行散射校正时，作为安慰剂给予生理盐水前后测量值的差异为0.5±8.4%。对相同区域进行散射校正测量时，差异为 - 0.2±12.6%。这些结果表明，无论是否进行散射校正，给予安慰剂均不影响测量值。在4名静息受试者的64个脑区连续两天进行测量时，两天测量值之间的差异为 - 1.1±9.0%。给予乙酰唑胺后，相同区域的差异为 - 4.0±11.7%。这些结果表明，无论是受试者静息时还是给予乙酰唑胺时，测量结果都是可重复的。上述两种方法用于对相同的5名受试者的80个脑区进行测量以作比较。静息受试者和给予乙酰唑胺受试者的测量在不同日期进行。静息受试者得到回归直线y = 0.99x + 1.47，r = 0.80，给予乙酰唑胺受试者得到回归直线y = 0.86x + 7.76，r = 0.76。这些结果表明，两种方法获得的值之间具有良好的相关性。因此，松田和竹内等人的方法在乙酰唑胺给药前后获得的值与先前使用传统方法报道的值一致，并且前一种方法被证明既简单又可靠。
