Schad H, Seller H
Pflugers Arch. 1976 May 12;363(2):155-9. doi: 10.1007/BF01062284.
In conscious cats with intact or denervated baroreceptors volume expansion of 5-15% of blood volume was performed with dextran and isotonic sodium chloride. Renal sympathetic activity (RSA), electroencephalogram (EEG) blood pressure (BP) and heart rate (HR) were recorded. RSA was reduced by 25-85% in 10 experiments out of 11 by volume expansion both with dextran and isotonic sodium chloride. Reduction of RSA could not be related to different states of wakefulness as indicated by the EEG, so could only be caused by volume expansion, although no quantitative correlation could be detected. No differences were observed between animals with intact and denervated baroreceptor. In most experiments BP and HR decreased during volume expansion up to -25 mmHg and up to -23 beats/min, respectively. The degree of BP and HR reduction could not be related to the degree of RSA reduction. The results suggest that changes in RSA might be involved in the renal response to volume expansion.
在清醒的猫身上，通过右旋糖酐和等渗氯化钠对血量进行5%-15%的扩容，这些猫的压力感受器完整或已去神经支配。记录肾交感神经活动（RSA）、脑电图（EEG）、血压（BP）和心率（HR）。在11个实验中的10个实验里，无论是使用右旋糖酐还是等渗氯化钠进行扩容，RSA都降低了25%-85%。如脑电图所示，RSA的降低与不同的清醒状态无关，所以只能是由扩容引起的，尽管未检测到定量相关性。在压力感受器完整和去神经支配的动物之间未观察到差异。在大多数实验中，扩容期间血压和心率分别下降至-25 mmHg和-23次/分钟。血压和心率降低的程度与RSA降低的程度无关。结果表明，RSA的变化可能参与了肾脏对容量扩张的反应。
