Ebata M, Fukuda Y, Nakano I, Katano Y, Fujimoto N, Hayakawa T
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Liver. 1997 Dec;17(6):293-9. doi: 10.1111/j.1600-0676.1997.tb01035.x.
Serum levels of tissue inhibitor of metalloproteinases-2 (TIMP2) and of precursor form of matrix metalloproteinase-2 (proMMP2) were determined in patients with chronic hepatitis and hepatocellular carcinoma by a one-step sandwich enzyme immunoassay. Serum levels of TIMP2 and proMMP2 were significantly higher in patients with chronic liver disease, than in normal controls. Serum levels of TIMP2 showed a weak negative correlation with the serum albumin level and prothrombin time (PT). Serum levels of proMMP2 in patients with chronic hepatitis were strongly correlated with those of type IV collagen and were negatively correlated with PT and serum albumin levels. Serum proMMP2 levels were also significantly correlated with histological stages. These data indicate that serum levels of proMMP2 might be useful in the follow-up of patients with chronic hepatitis.
采用一步夹心酶免疫分析法测定慢性肝炎和肝细胞癌患者血清中金属蛋白酶组织抑制剂-2（TIMP2）和基质金属蛋白酶-2前体（proMMP2）的水平。慢性肝病患者血清中TIMP2和proMMP2水平显著高于正常对照组。TIMP2血清水平与血清白蛋白水平及凝血酶原时间（PT）呈弱负相关。慢性肝炎患者血清proMMP2水平与IV型胶原水平呈强相关，与PT及血清白蛋白水平呈负相关。血清proMMP2水平也与组织学分期显著相关。这些数据表明，血清proMMP2水平可能对慢性肝炎患者的随访有帮助。
