McCann S J, Pond S M, James K M, Le Couteur D G
Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.
J Neurol Sci. 1997 Dec 9;153(1):50-3. doi: 10.1016/s0022-510x(97)00179-2.
We performed a case-control study to investigate the association of the poor metaboliser genotype of the cytochrome P450 2D6 gene with Parkinson's disease (PD). Genotyping was determined by the polymerase chain reaction followed by digestion with restriction enzymes. The poor metaboliser genotype was more frequent in 112 patients with PD than in 206 matched controls (odds ratio 1.7, 95% CI: 0.94-2.45). A meta-analysis of these results together with ten other published studies gave a pooled odds ratio for the poor metaboliser genotype of 1.47 (95% CI: 1.18-1.96, P=0.01). Thus, the poor metaboliser genotype has a small but highly significant association with PD which would be easily missed in small studies. Research now should focus on the mechanism of this association.
我们开展了一项病例对照研究，以调查细胞色素P450 2D6基因代谢不良者基因型与帕金森病（PD）之间的关联。通过聚合酶链反应，随后用限制性酶消化来确定基因分型。112例PD患者中代谢不良者基因型的频率高于206例匹配对照（优势比1.7，95%可信区间：0.94 - 2.45）。对这些结果与其他十项已发表研究进行的荟萃分析得出，代谢不良者基因型的合并优势比为1.47（95%可信区间：1.18 - 1.96，P = 0.01）。因此，代谢不良者基因型与PD存在小但高度显著的关联，这在小型研究中很容易被忽视。现在的研究应聚焦于这种关联的机制。
