Brzóska M M, Moniuszko-Jakoniuk J
Department of Toxicology, Medical Academy, Bialystok, Poland.
Arch Toxicol. 1998;72(2):63-73. doi: 10.1007/s002040050470.
Voluminous literature data show that great interdependence exists between the nutrition status of the organism and the degree of accumulation and toxicity of heavy metals. In this work, the connection between dietary calcium and cadmium toxicity is discussed from the toxicological point of view. Cadmium is one of the most dangerous occupational and environmental poisons. The intake of diet containing an inappropriate amount of calcium causes increased absorption of cadmium from the gastrointestinal tract and increased accumulation of this metal in the organism, finally leading to enhancement of cadmium toxic action. The large intake of calcium protects against absorption, cumulation and toxicity of this heavy metal. Interactions between calcium and cadmium may take place at different stages of their metabolism (absorption, distribution in the organism, elimination) and cadmium may interfere with the biological functions of Ca2+ ions.
大量的文献资料表明，生物体的营养状况与重金属的积累程度和毒性之间存在着密切的相互关系。在这项工作中，从毒理学角度探讨了膳食钙与镉毒性之间的联系。镉是最危险的职业和环境毒物之一。摄入含钙量不当的饮食会导致胃肠道对镉的吸收增加，以及这种金属在生物体内的积累增加，最终导致镉毒性作用增强。大量摄入钙可防止这种重金属的吸收、积累和毒性。钙和镉之间的相互作用可能发生在它们代谢的不同阶段（吸收、在生物体内的分布、排泄），并且镉可能会干扰Ca2+离子的生物学功能。
