Langford A M, Taylor K K, Pounder D J
Department of Forensic Medicine, University of Dundee, Scotland.
J Forensic Sci. 1998 Jan;43(1):22-7.
We evaluated the homogeneity of drug concentrations in muscle in 14 cadavers, comprising 11 drug overdoses and three cases of chronic therapeutic drug use. Analyses were performed on samples from twelve named muscles and femoral venous blood. Standard analytical techniques and instrumentation were used throughout. There was marked within-case variability in drug concentrations with highest:lowest concentrations ranging up to 21.7. Overall highest concentrations were found in the diaphragm and mean diaphragm:blood ratios ranged from 1.1 (temazepam, two cases) and 1.2/1.3 (paracetamol, six cases) up to 6.5/13.5 (amitriptyline, three cases) and 5.3/21.3 (propoxyphene, four cases). Excluding the diaphragm, mean muscle:blood ratios ranged from 0.4 (prothiaden), 0.5 (temazepam), and 0.7 (paracetamol) up to 3.7 (temazepam), 4.3 (propoxyphene) and 5.7 (amitriptyline). We suggest that muscle is suitable for qualitative analysis but not for quantitative corroboration of a blood sample or as a quantitative alternative to blood.
我们评估了14具尸体肌肉中药物浓度的均匀性，其中包括11例药物过量和3例慢性治疗性药物使用病例。对来自12块指定肌肉和股静脉血的样本进行了分析。整个过程采用了标准分析技术和仪器。病例内药物浓度存在显著差异，最高浓度与最低浓度之比高达21.7。总体而言，膈肌中的药物浓度最高，膈肌与血液的平均比值范围从1.1（替马西泮，2例）和1.2/1.3（对乙酰氨基酚，6例）到6.5/13.5（阿米替林，3例）和5.3/21.3（丙氧芬，4例）。排除膈肌后，肌肉与血液的平均比值范围从0.4（丙硫异戊嗪）、0.5（替马西泮）和0.7（对乙酰氨基酚）到3.7（替马西泮）、4.3（丙氧芬）和5.7（阿米替林）。我们认为，肌肉适用于定性分析，但不适用于对血样进行定量确证，也不能作为血液的定量替代物。
